QSAR Modeling Of Mammal Acute Toxicity By Oral Exposure
نویسندگان
چکیده
منابع مشابه
QSAR modeling of acute toxicity on mammals caused by aromatic compounds: the case study using oral LD50 for rats.
The goal of the study was to predict toxicity in vivo caused by aromatic compounds structured with a single benzene ring and the presence or absence of different substituent groups such as hydroxyl-, nitro-, amino-, methyl-, methoxy-, etc., by using QSAR/QSPR tools. A Genetic Algorithm and multiple regression analysis were applied to select the descriptors and to generate the correlation models...
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2.1.Date of QMRF: 03.09.2009 2.2.QMRF author(s) and contact details: [1]Indrek Tulp Molcode Ltd. Turu 2, Tartu, 51014, Estonia [email protected] http://www.molcode.com [2]Tarmo Tamm Molcode Ltd. Turu 2, Tartu, 51014, Estonia [email protected] http://www.molcode.com [3]Gunnar Karelson Molcode Ltd. Turu 2, Tartu, 51014, Estonia [email protected] http://www.molcode.com [4]Dimitar Dobchev Molcod...
متن کاملAcute oral toxicity.
The purposes of acute toxicity testing are to obtain information on the biologic activity of a chemical and gain insight into its mechanism of action. The information on acute systemic toxicity generated by the test is used in hazard identification and risk management in the context of production, handling, and use of chemicals. The LD50 value, defined as the statistically derived dose that, wh...
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Objective: The plantCassia fistula L. (Caesalpiniaceae) is traditionally used to treat heart diseases, abdominal pain and fever. The present study was aimed to investigate the toxic effects acute and sub-acute administration of ethanol extract of C. fistula fruit (CFE) in male Wistar rats. Materials and Methods: In acute toxicity, the effects of a single oral dose (1000, 3000 and 5000 mg/kg) of...
متن کاملQSAR modelling of acute toxicity in the fathead minnow
There are more than 70000 chemicals in use today and many more being synthesized. It is vital to assess the influence of these compounds on the environment and on human health. Experimental testing is both time-consuming and expensive, and accordingly, there is a pressing requirement for accurate in silico methods to assess the toxicity. QSAR studies of the environmental fate of chemicals are w...
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ژورنال
عنوان ژورنال: Biomedical Chemistry: Research and Methods
سال: 2018
ISSN: 2618-7531
DOI: 10.18097/bmcrm00066